Thyrox 25 (Pot) 100Pcs

Indications

A medication called Thyrox 25 is used to treat an underactive thyroid gland (hypothyroidism). It helps control your body's energy and metabolism by replacing the hormone that your thyroid gland was not producing enough of. Your doctor will perform a blood test before you begin taking Thyrox 50 to determine the dosage you require. After you begin taking the medication, you will undergo routine blood tests to determine how well it is working, and the dose may occasionally be changed. Exactly as prescribed by your doctor, take this medication.

Pharmacology

Thyrox 25 mg tablet contains synthetic levothyroxine, also known as thyroxine or T4, which is identical to the thyroid hormone T4 found in nature. About 30% of T4 is converted to the much more active triiodothyronine in peripheral tissues (T3). T4 is primarily carried by TBG (Thyroxine Binding Globulin). T4 has a prolonged half-life in the body as a result of this binding, which shields it from metabolism and excretion.

Dosage & Administration

Adult dose:

• Initial starting dose: 25–50 meg/day; as needed, the dose may be gradually increased every 6–8 weeks. Until the patient with primary hypothyroidism is clinically euthyroid and the serum TSH has normalized, the dose of levothyroxine sodium is typically increased by 12.5 to 25 meg.
• Until the TSH level is normalized, patients with severe hypothyroidism should take an initial dose of 12.5–25 mg/day, increasing by 25 mg/day every 2-4 weeks, while also receiving clinical and laboratory evaluations.
• In patients with secondary (pituitary) or tertiary (hypothalamic)
• Hypothyroidism: The serum-free-T4 level should be raised to the upper half of the normal range and the dose of Levothyroxine Sodium should be increased until the patient is clinically euthyroid.
• 1.7 mg/kg/day for patients with underlying cardiac disease who are over 50 or who are under 50.

Pediatric Dosage Newborns: 

A starting dose of 10-15 mg/kg/day is advised. Infants at risk for cardiac failure should start with a lower dose, and if necessary, the dose should be increased in 4-6 weeks based on clinical and laboratory responses to treatment. The initial starting dose of 50 mg/day of levothyroxine sodium is advised for infants with very low serum T4 concentrations (5 mcg/dL) or undetectable serum T4 concentrations.

Infants and Children:

The initial dose of 25 mg/day with increases of 25 mg every 2-4 weeks until the desired effect is achieved in children with chronic or severe hypothyroidism. If the starting dose is one-fourth of the recommended full replacement dose and the dose is then increased on a weekly basis by an amount equal to one-fourth of the recommended full replacement dose until the recommended full replacement dose is reached, hyperactivity in an older child can be minimized.

• Age 0 to 3: 10-15 meg/kg/day
• 3 to 6 months: 8 to 10 meg/kg/day
• 6 to 12 months: 6 to 8 meg/kg/day.
• Ages 1 to 5: 5 to 6 meg/kg/day
• 6–12 years: 4-5 meg/kg/day >12 years, but incomplete development and
• puberty: 2-3 mg/kg per day
• Complete growth and puberty: 1.7 mg/kg/day.

Based on clinical response and laboratory parameters, the dose should be modified. The goal of goiter, nodule, and thyroid cancer treatment is to maintain consistent and adequate TSH suppression. A gradual increase in dosage is typically not required for TSH suppression. T4 is typically administered suppressively to adults at a dose of 2.6 mg/kg of body weight per day. The dosage of levothyroxine sodium depends on the type of investigation being conducted when it is used as a diagnostic aid.

Interaction

Iron, antacids, bile acid sequestrants, colestyramine, simethicone, calcium carbonate, sucralfate, and cation exchange resins all reduce absorption. Tri-iodothyronine serum levels were decreased while taking amiodarone and propranolol. Thyroxine levels in the serum were decreased when combined with carbamazepine, phenytoin, phenobarbital, rifampicin, lithium, estrogens, and sertraline. Levothyroxine-binding globulin serum levels may be reduced by androgens. may change the amount of antidiabetic medication needed. increased risk of tachycardia and severe HTN when using ketamine. Added metabolic requirements from sympathomimetics (e.g. epinephrine). Warfarin's anticoagulant effect could become stronger.

Contraindications

Overdosing can cause hyperthyroidism symptoms like tachycardia, agitation, tremor, headache, flushing, perspiration, and weight loss. Treatment can be stopped for a few days and then resumed at a lower dose if necessary.

Side Effect

• Palpitations
• Vomiting
• Anxiety
• Diarrhea
• Menstrual irregularities
• Weight loss
• Nervousness
• Restlessness
• Flushing (sense of warmth in the face, ears, neck, and trunk)
• Increased bone resorption and reduced bone mineral density

Pregnancy & Lactation

Category A Pregnancy. The need for Levothyroxine may increase during pregnancy. Although thyroid hormones are excreted in small amounts in human milk, caution should be maintained when given to a nursing mother. To maintain regular lactation, however, appropriate replacement doses of Levothyroxine are usually required.

Precautions & Warnings

• Thyrox 25 ought to be taken empty-handed (ideally, first thing in the morning). One hour before and two hours after taking this medication, you shouldn't eat, drink any milk, or have any tea. The full impact might not be felt for six to eight weeks.
  Thyrox 25 can be a lifelong medication for the majority of people. Without first consulting, your doctor does not stop taking it.
• If you experience diarrhea, anxiety, irritability, disturbed sleep, shaking hands, or chest pain, let your doctor know. Your dose may be changed by your doctor.
  Before taking any antacids, calcium or iron supplements, or multivitamins, wait at least 4 hours as these may interfere with the medication's effectiveness.
• Keep in mind that a "high" normal to slightly elevated T4 level will be required in order to obtain a normal level of T3 when observing blood levels of T3 and T4. Levothyroxine dosage for primary hypothyroidism should typically be determined by checking to see if the serum TSH level has normalized. If you notice a significant change in your body weight, notify your doctor and have your hormone levels checked on a regular basis. It might be necessary to change the dose.
• Before switching the brand of Thyrox 25 you're using, let your doctor know as not all brands will have the same effect.

Storage Conditions

Protect from light and store in a cool, dry location. Keep out of children's reach.